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ea0022p706 | Obesity | ECE2010

The influence of weight-loss induced by bariatric surgery on serum concentrations of novel metabolic regulators FGF-21 and FGF-19 in morbidly obese subjects

Haluzikova Denisa , Bartlova Marketa , Mraz Milos , Lacinova Zdena , Krizova Jarmila , Kavalkova Petra , Trachta Pavel , Michalsky David , Kasalicky Mojmir , Haluzik Martin

Objective: Fibroblast growth factor 19 (FGF-19) and FGF-21 are novel metabolic regulators that improve insulin resistence and obesity in rodents. The objective of this study was to explore whether changes in serum concentrations of FGF-19 and FGF-21 contribute to positive metabolic effects of weight loss induced by surgical treatment of obesity sleeve gastrectomy (SG).Methods: Serum concentrations of FGF-19 and 21, adiponectin, resistin, fatty aci...

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ea0022p159 | Cardiovascular endocrinology and lipid metabolism | ECE2010

Changes in serum concentrations and tissue expression of fibroblast growth factor-21 during and after elective major cardiac surgery

Drapalova Jana , Kotulak Tomas , Kopecky Petr , Mraz Milos , Riha Hynek , Blaha Jan , Kramar Petr , Netuka Ivan , Maly Jan , Kremen Jaromir , Kotrlikova Eva , Svacina Stepan , Haluzik Martin

Introduction: Fibroblast growth factor-21 (FGF-21) is a novel regulator of glucose and lipid metabolism and insulin sensitivity. Possible role of FGF-21 in the development of insulin resistance in critically ill patients has not been studied yet.Objective: To study the changes in FGF21 production and adipose tissue and skeletal muscle FGF-21 mRNA gene expression in cardiac surgery patients.Methods: Sixteen patients (16 men, aged 66...

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Endocrine Abstracts

The influence of weight-loss induced by bariatric surgery on serum concentrations of novel metabolic regulators FGF-21 and FGF-19 in morbidly obese subjects

Changes in serum concentrations and tissue expression of fibroblast growth factor-21 during and after elective major cardiac surgery

BiosciAbstracts